In D2R Ladder Items, runes are one pocketable item you can use to enhance your gear from the endgame with some other bonuses. But if you install runes in a particular order with a specific item, you receive a unique little bit of gear called a Runeword. Those items are some of the most effective gear from the game, but you are fiddly - if one makes a mistake slotting the runes to your gear, you need to destroy them to make it right. New Runewords in many cases are added in patches, and Blizza...